Core–Shell Pd@Au Nanoplates as Theranostic Agents for In‐Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy

TLDR

The study aims to demonstrate the advantages of 2D Pd@Au core–shell nanoplates for in vivo biomedical imaging and therapy. Pd@Au core–shell nanoplates were synthesized via a seeded growth strategy to yield uniform plasmonic bimetallic structures. SH‑PEG functionalization confers biocompatibility, extended circulation, and tumor accumulation, enabling enhanced photoacoustic/CT contrast and efficient photothermal ablation guided by imaging.

Abstract

Uniform plasmonic Pd@Au core–shell bimetallic nanoplates are synthesized by seeded growth strategy. Surface modified with SH-PEG makes it good biocompatibility, prolonged blood circulation, and relatively high tumor accumulation. Enhanced tumor contrast effects can be obtained for in vivo photoacoustic/CT imaging after intravenous injection of Pd@Au-PEG. Moreover, efficient photothermal tumor ablation is achieved, guided by the imaging techniques. This work promises further exploration of the superiority of 2D nanostructures for in vivo biomedical applications.