Advanced Materials · 2014 · 425 citations · 40 references
EngineeringBioengineeringBiomedical EngineeringBiomedical ImagingNanomaterialsTheranosticsCancer NanomedicineNanomaterials SynthesisNanomedicinePhotoacoustic ImagingPhotothermal TherapyTheranostic NanoparticlesBiomedical ApplicationsNanomaterials For Photothermal TherapyPhotothermal Ablation Of TumorsSeeded GrowthTheranostic AgentsTheranostic Imaging AgentsTheranostic NanomaterialsTheranostic Nanomedicine
The study aims to demonstrate the advantages of 2D Pd@Au core–shell nanoplates for in vivo biomedical imaging and therapy. Pd@Au core–shell nanoplates were synthesized via a seeded growth strategy to yield uniform plasmonic bimetallic structures. SH‑PEG functionalization confers biocompatibility, extended circulation, and tumor accumulation, enabling enhanced photoacoustic/CT contrast and efficient photothermal ablation guided by imaging.
Uniform plasmonic Pd@Au core–shell bimetallic nanoplates are synthesized by seeded growth strategy. Surface modified with SH-PEG makes it good biocompatibility, prolonged blood circulation, and relatively high tumor accumulation. Enhanced tumor contrast effects can be obtained for in vivo photoacoustic/CT imaging after intravenous injection of Pd@Au-PEG. Moreover, efficient photothermal tumor ablation is achieved, guided by the imaging techniques. This work promises further exploration of the superiority of 2D nanostructures for in vivo biomedical applications.
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