Influence of Age, Race, Sex, and Body Mass Index on Interpretation of Midregional Pro Atrial Natriuretic Peptide for the Diagnosis of Acute Heart Failure: Results from the BACH Multinational Study

Abstract

Age, race, sex, and BMI affect MR-proANP levels to various degrees. However, the diagnostic performance of the recommended cut-off point of 120 pmol/L to rule out acute HF was robust across most subgroups. Although both sex and BMI affected MR-proANP levels, they did not alter its overall diagnostic performance. Lower cut-off points for MR-proANP could be considered in younger patients and in patients with a higher BMI, to optimize diagnostic sensitivity.