Enantiomerically Pure N-Boc Protected β-Keto-γ-Amino Acid Esters from Simple Keto Precursors: A Novel, Stereocontrolled Approach to Statine Derivatives with Any Desired Configuration¹

Abstract

A simple, short, and chiral-pool-independent method for the preparation of enantiomerically pure statine precursors is described, using 1-phenylethylamine as an inexpensive chiral auxiliary, commercially available in both enantiomeric forms.