Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients

Abstract

This is the first report demonstrating that ABCB1 polymorphisms influence cyclosporine intracellular concentration. Interestingly, its influence on intracellular concentration is significantly higher than on blood concentration (P<0.002). This may therefore modulate cyclosporine immunosuppressive activity.