Sphingosine-1-Phosphate and Its Analogue FTY720 Diminish Acute Pulmonary Injury in Rats With Acute Necrotizing Pancreatitis

Abstract

Sphingosine-1-phosphate and its analogue FTY720 significantly decreased pulmonary inflammation and injury in a rat model of acute lung injury caused by acute necrotizing pancreatitis and may represent a novel therapeutic strategy for the acute necrotizing pancreatitis-associated lung injury.