Perinatal Significance of Isolated Maternal Hypothyroxinemia Identified in the First Half of Pregnancy

Abstract

Isolated maternal hypothyroxinemia has no adverse effects on perinatal outcome. Moreover, unlike subclinical hypothyroidism, there was a low prevalence of thyroid peroxidase antibodies and no correlation between TSH and free T(4) levels in women with hypothyroxinemia, leading us to question its biological significance.