Chemistry - A European Journal · 1999 · 56 citations · 0 references
Life SciencesBiochemistryMolecular BiologyBioorthogonal ChemistryNucleic Acid BiochemistryNucleic Acid ChemistryBase PairingBase StackingNucleic Acid StructureNucleic Acid SynthesisOligonucleotide ChemistryRibonucleic Acid (Rna) ChemistryBase Pairing InteractionsDna Base PairingNucleobase Base PairingOligonucleotide HybridizationRna Base PairingWatson-crick Base PairingWatson-crick Base PairsWatson-crick Pairing
Cyclohexanyl nucleic acid (CNA) represents a novel enantioselective Watson–Crick base-pairing system. Homochiral oligomers of equivalent chirality show antiparallel Watson–Crick pairing, while those of opposite sense do not. D-CNA hybridizes with natural nucleic acids, preferentially with RNA. A conformational change involving chair inversion is expected to occur upon duplex formation (A→B).