HYDROGEN PEROXIDE FORMATION IN THE RAT UTERUS UNDER HORMONE-INDUCED CONDITIONS

Abstract

The production of hydrogen peroxide was quantitated in the uterus of cyclic, ovariectomized (treated with hormones) and pregnant (days 1-6 post coitum) rats. This phenomenon was found to be dependent on oestrogen. The uterine responsiveness to hydrogen peroxide was correlated with peroxidase-catalysed inactivation of oestrogens in this target organ.