Publication | Closed Access
INFLUENCE OF THYROTROPHIC HORMONE ON CONNECTIVE TISSUE PATHOGENETIC SIGNIFICANCE OF MUCOPOLYSACCHARIDES IN EXPERIMENTAL EXOPHTHALMOS
88
Citations
0
References
1951
Year
Metabolic RateOphthalmologyPathogenesisImmunologyAnterior Pituitary ExtractsPathologyMonstrous MyxoedemaThyroid DiseaseThyroid DisordersPituitary DiseaseParathyroid GlandThyroid HormoneOcular Surface PhysiologyEndocrinologyMedicine
Exophthalmos is due to an exophthalmogenic factor produced by the anterior lobe of the pituitary gland and closely related to the thyrotrophic hormone. It has been shown by recent experiments that iodination of anterior pituitary extracts with a thyrotrophic effect completely eliminates the thyroid stimulating effect, whereas the exophthalmic principle is preserved (Jefferies, 1949 a). Localized, thyrotoxic myxoedema presents pretibial, circumscribed, often monstrous myxoedema combined with malignant exophthalmos, an increased metabolic rate, and other thyrotoxic symptoms. The condition has been attributed to an overproduction of thyrotrophin (Trotter & Eden, 1942, Vilanova & Canadell, 1949).