Chromosomes and causation of human cancer and leukemia.VII. The significance of the Ph1 in conditions other than CML

Abstract

Two cases of Ph1-positive AML, and one case of Di Guglielmo's syndrome are reported. A review of the literature reveals that the occurrence of a Ph1-chromosome has been observed in a number of cases with these diseases, indicating that the Ph1-chromosome is not solely specific for CML. By correlating cytogenetic and histologic bone marrow data, some evidence is presented that the process leading to the genesis of a Ph1-chromosome may affect the bone marrow cells either at or beyond the stem cell level.