<i>KVLQT1</i> C-Terminal Missense Mutation Causes a Forme Fruste Long-QT Syndrome

Abstract

Our data show a wide KVLQT1 allelic heterogeneity among 20 families in which KVLQT1 causes RWS. We describe the first missense mutation in the C-terminal domain of KVLQT1, which is clearly associated with a fruste phenotype, which could be a favoring factor of acquired LQT syndrome.