Publication | Open Access
High Relaxivity for Monomeric Gd(DOTA)-Based MRI Contrast Agents, Thanks to Micellar Self-Organization
119
Citations
0
References
1999
Year
Supramolecular AssemblyEngineeringHigh RelaxivityImaging AgentMagnetic ResonanceChemistryMagnetic Resonance ImagingRadiologyRelaxometryMedical ImagingAqueous SolutionMicelleNeuroimagingMicellar Self-organizationContrast AgentMri-guided Radiation TherapyBiomolecular EngineeringBiomedical ImagingMri Contrast AgentsAmphiphilic SystemNeuroscienceHigh Proton RelaxivitiesMacromolecular ComplexesMedicineSynthetic Chemistry
A new amphiphilic GdIII chelate, which is capable of forming micelles in aqueous solution (see diagram), has been synthesized. Due to this self-aggregation, the compound has a long rotational correlation time and, consequently, has high proton relaxivities that thus far have only been obtained with macromolecular complexes.