DNA Double-Strand Breaks and Their Repair in Blood Lymphocytes of Patients Undergoing Angiographic Procedures

Abstract

gamma-H2AX immunofluorescence microscopy is a reliable and sensitive method for measuring the induction and repair of DNA damage caused by ionizing radiation during angiography. To estimate radiation doses delivered during procedures and to consider patients individual repair capacity, postangiography DSB-yields should be compared with DSB-yields after fractioned in vitro irradiation imitating examination conditions.