Regulation of vascular nitric oxide <i>in vitro</i> and <i>in vivo</i>; a new role for endogenous hydrogen sulphide?

Abstract

These results suggest that H2S and NO react together to form a molecule (possibly a nitrosothiol) which exhibits little or no vasorelaxant activity either in vitro or in vivo. We propose that a crucial, and hitherto unappreciated, role of H2S in the vascular system is the regulation of the availability of NO.