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An Efficient Domino Synthesis of Quinoxalin‐2(1<i>H</i>)‐ones <i>via</i> an S<sub>N</sub>Ar/Coupling/Demesylation Reaction Catalyzed by Copper(I) as Key Step
67
Citations
34
References
2010
Year
Key StepEngineeringOrganic ChemistryChemistryChemical EngineeringMedicinal ChemistryOrganometallic CatalysisEfficient Copper‐catalyzed MethodEfficient Domino SynthesisCross-coupling ReactionDerivativesDiversity-oriented SynthesisCatalysisSynthesis MethodVarious QuinoxalinonesPharmaceutical ActivitiesEnantioselective SynthesisBiomolecular EngineeringNatural SciencesSynthetic Chemistry
Abstract An efficient copper‐catalyzed method for the synthesis of quinoxalin‐2(1 H )‐ones derivatives via domino S N Ar/coupling/demesylation reaction of N ‐(2‐halophenyl)methylsulfonamides with 2‐halo amides has been developed. Various quinoxalinones with diversity at three positions on their scaffold have been obained, and the method is valuable for the construction of this kind of molecules with biological and pharmaceutical activities.
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