Concepedia

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

Evguenia Strom, Swati Sathe, Pavel G. Komarov, Olga Chernova, Ivanda Pavlovska, Inna Shyshynova, Dmitry A. Bosykh, Lyudmila G. Burdelya, Roger M. Macklis, Rami Skaliter,

Nature Chemical Biology · 2006 · 325 citations · 21 references

DOI

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References

21

p53 is required for radiation-induced apoptosis in mouse thymocytes

Scott W. Lowe, Earlene M. Schmitt, Sallie W. Smith et al. · Nature · 1993 · 2.9K citations

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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

Jerry E. Chipuk, Tomomi Kuwana, Lisa Bouchier‐Hayes et al. · Science · 2004 · 2K citations

, , +15

p53 Has a Direct Apoptogenic Role at the Mitochondria

Motohiro Mihara, Susan Erster, Alexander Zaika et al. · Molecular Cell · 2003 · 1.8K citations · Full text

, , +12

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

Patrick Dumont, Julia I-Ju Leu, Anthony C. Della Pietra et al. · Nature Genetics · 2003 · 1.3K citations

, , +13

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

Pavel G. Komarov, Elena A. Komarova, Roman V. Kondratov et al. · Science · 1999 · 1.3K citations

, , +17