Virus-Induced Hydrocephalus: Development of Aqueductal Stenosis in Hamsters after Mumps Infection

Abstract

Hydrocephalus developed as a sequela of mumps virus infections of suckling hamsters. The initial infection after intracerebral inoculation was limited largely to ependymal cells lining the ventricles. This infection was clinically inapparent but later resulted in a noninflammatory stenosis or occlusion of the aqueduct of Sylvius.