Drug Delivery and Translational Research · 2012 · 116 citations · 79 references
VaccinologyVaccinationMucosal VaccinationVaccine DevelopmentIntranasal DeliveryDelivery SystemsVaccine FormulationsImmunologyTherapeutic VaccineVaccine DesignImmune SystemMedicineViral Immunity
Most human pathogens colonize mucosal surfaces, and recent efforts now emphasize stimulating local immunity there in addition to systemic responses. This review aims to describe vaccine formulations for intranasal delivery to the nasal‑associated lymphoid tissue to prevent infection at mucosal sites. It focuses on antigen–adjuvant combinations and delivery systems that target the nasal‑associated lymphoid tissue for intranasal vaccination.
The vast majority of human pathogens colonize and invade at the mucosal surfaces. Preventing infection at these sites via mucosally active vaccines is a promising and rational approach for vaccine development. However, it is only recently that the stimulation of local immunity at the mucosal surfaces has become a primary objective in addition to inducing systemic immunity. This review describes vaccine formulations designed for mucosal delivery to the nasal-associated lymphoid tissue, via intranasal administration. The association of antigens with mucosal adjuvants and delivery systems is emphasised.
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Melinda Fitzgerald, Ian P. Hayward, Anita C. Thomas et al. · 1995 · 2.6K citations
CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
Zina Moldoveanu, Laurie Love-Homan, Wen Huang et al. · Vaccine · 1998 · 312 citations