Concepedia

Pseudomonas aeruginosa quorum sensing as a potential antimicrobial target

Roger S. Smith, Barbara H. Iglewski

Journal of Clinical Investigation · 2003 · 222 citations · 37 references

DOIFull text

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Concepts

Abstract

Pseudomonas aeruginosa has two complete quorum-sensing systems. Both of these systems have been shown to be important for Pseudomonas virulence in multiple models of infection. Thus, these systems provide unique targets for novel antimicrobial drugs.

References

37

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

Morten Hentzer · The EMBO Journal · 2003 · 1.4K citations · Full text

, , +5

Identification, Timing, and Signal Specificity of<i>Pseudomonas aeruginosa</i>Quorum-Controlled Genes: a Transcriptome Analysis

Martín Schuster, Phoebe Lostroh, Tomoo Ogi et al. · Journal of Bacteriology · 2003 · 1.1K citations · Full text

Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.

James P. Pearson, K M Gray, Luciano Passador et al. · Proceedings of the National Academy of Sciences · 1994 · 986 citations · Full text

, , +12

Microarray Analysis of <i>Pseudomonas aeruginosa</i> Quorum-Sensing Regulons: Effects of Growth Phase and Environment

Victoria Wagner, Daniel Bushnell, Luciano Passador et al. · Journal of Bacteriology · 2003 · 912 citations · Full text

, , +15

A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa.

James P. Pearson, Luciano Passador, Barbara H. Iglewski et al. · Proceedings of the National Academy of Sciences · 1995 · 786 citations · Full text

, , +14