Molecular Basis of P2-Receptor-Mediated Calcium Signaling in Activated Pancreatic Stellate Cells

Abstract

Activated PSC feature a plethora of elements from the Ca signaling toolkit and functionally express a subset of P2 nucleotide receptors. Purines and pyrimidines elicit robust intracellular Ca(2+) signals likely contributing to the fibrogenetic potential of these cells.