Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Ruslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature · 1997 · 5.5K citations

Life Sciences, Immunology, Molecular Biology +13

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Katherine A. Fitzgerald, Sarah M. McWhirter, Daniel C. Rowe et al. · Nature Immunology · 2003 · 2.7K citations

Life Sciences, Biochemistry, Molecular Biology +6

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

Ebrahim Zandi, David M. Rothwarf, Mireille Delhase et al. · Cell · 1997 · 1.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

Taro Kawai, Osamu Takeuchi, Takashi Fujita et al. · The Journal of Immunology · 2001 · 1.1K citations · Full text

Life Sciences, Immunology, Microbiology +16

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

Shoji Yamaoka, Gilles Courtois, Christine Bessia et al. · Cell · 1998 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14