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Studies on Formosan Soft Corals, II. Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae
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1992
Year
EngineeringCoral EcosystemsCoral PhysiologyCoral Reef EcologyChcl3 ExtractCoral ReefCytotoxic CembranolidesBiochemistryAlgal BiologyPharmacologyNew Cytotoxic CembranolideFormosan Soft CoralsBiomolecular EngineeringBiologyNatural SciencesBioactivity-guided FractionationPhycologyMarine BiologyDrug Discovery
Bioactivity-guided fractionation of a CHCl3 extract of the soft coral Lobophytum michaelae afforded a new cytotoxic cembranolide, lobomichaolide (1), and a known cytotoxic cembranolide, crassolide (2). The structure of 1 was determined by spectral and X-ray crystallographic analysis.