Desymmetrizing asymmetric ring expansion: stereoselective synthesis of 7-membered cyclic β-keto carbonyl compounds with an α-hydrogen

Abstract

Ring expansion of symmetrically substituted cyclohexanones with N-alpha-diazoacetyl camphorsultam was devised as a stereoselective pathway to the functionalized 7-membered cyclic beta-keto carbonyls having a kinetically stabilized alpha-hydrogen.