Concepedia

CORTICOTROPIN-RELEASING FACTOR (CRF): CENTRAL EFFECTS ON MEAN ARTERIAL PRESSURE AND HEART RATE IN RATS.

Laurel A. Fisher, EAN JRIVIER, Catherine Rivier, Joachim Spiess, Wylie Vale, Marvin R. Brown

Endocrinology · 1982 · 262 citations · 11 references

DOI

Concepts

Abstract

Intracerebroventricular administration of corticotropin-releasing factor (CRF) produces elevations in mean arterial pressure and heart rate in conscious freely-moving rats. Pretreatment with the ganglionic blocker, chlorisondamine, completely prevents the CRF-induced cardiovascular changes. These results suggest that CRF acts within the brain to stimulate sympathetic nervous activity which in turn influences cardiovascular function.

References

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Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

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In Vivo Corticotropin-Releasing Factor-Induced Secretion of Adrenocorticotropin, β-Endorphin, and Corticosterone*

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Joachim Spiess, Jean Rivier, Catherine Rivier et al. · Proceedings of the National Academy of Sciences · 1981 · 428 citations

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Release of Vasopressin by Angiotensin II<sup>1</sup>

L. C. Keil, Joan Y. Summy‐Long, Walter B. Severs · Endocrinology · 1975 · 265 citations · Full text

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