Pubo-Urethral Ligament Transection Causes Stress Urinary Incontinence in the Female Rat: A Novel Animal Model of Stress Urinary Incontinence

Abstract

Our results demonstrate that deficiency of the pubo-urethral ligament in the female rat induces stress urinary incontinence comparable to that in a previously established model of pudendal nerve transection induced stress urinary incontinence. This novel rat model could be used to investigate the mechanisms of urethral hypermobility in female stress urinary incontinence or potential therapeutic interventions for stress urinary incontinence.