The Next Step in Biomimetic Material Design: Poly‐LacNAc‐Mediated Reversible Exposure of Extra Cellular Matrix Components

Abstract

Herein is demonstrated that a biomimetic, in-vivo-like presentation of extracellular matrix (ECM) proteins such as fibronectin, laminin, and collagen IV mediated by a fully functional poly-sugar (polyLacNAc)–lectin complex can be achieved on a biomaterials surface. Cells recognize and bind to these immobilized proteins and can, due to the reversible protein presentation, remodel initially presented ECM proteins.