Synthesis of ¹¹C‐pindolol

Abstract

Abstract A method is described by which 100 mCi of pindolol may be obtained from about 1.5 Ci 11 CO 2 in 30 minutes. The product is chromatographically pure, sterile and apyrogenic with a specific activity between 600 and 1000 mCi/μmole at the time of use. The synthesis involves the preparation of 11 C‐acetone followed by fixation of the isopropyl group on the precursor : 2 hydroxy‐3 (4‐indolyoxy) propylamine by formation of an imine, the reduction of the latter by sodium cyanoborohydride.