A Gold-Catalyzed Unique Cycloisomerization of 1,5-Enynes:  Efficient Formation of 1-Carboxycyclohexa-1,4-dienes and Carboxyarenes

Abstract

A novel Au-catalyzed migratory cycloisomerization strategy is advanced. Implementation of this strategy led to the development of a unique Au-catalyzed 1,5-enyne cycloisomerizatioin involving carboxy migration and Au-mediated C-C single bond formation. 1-Carboxycyclohexa-1,4-dienes and carboxyarenes can be prepared with good efficiency and with flexible substitution patterns.