Publication | Open Access
Familial, isolated, complete right bundle-branch block.
21
Citations
6
References
1975
Year
Genetic DisorderGeneticsGenetic EpidemiologyPediatricsLinkage AnalysisFamily StructureGenetic AnomalyMolecular GeneticsCongenital Heart DefectEighteenth CenturyParish RegistersMedicineCongenital Heart AnomalyCardiologyMendelian InheritanceCardiovascular Genetics
An electrocardiographic study of the families of two children with isolated complete right bundle-branch block is presented. Several cases of classical complete right bundle-branch block were disclosed (17/69 and 3/22 respectively) in three generations of the two families. Personal interviews and parish registers showed that the two families were related, being descendants 8 generations back from a glass-blower who has emigrated to Sweden in the eighteenth century. It is concluded that complete right bundle-branch block can be an autosomal, genetic anomaly which is inherited dominantly but with reduced penetrance and/or expressivity.
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