Endocrinology · 1951 · 112 citations · 0 references
Life SciencesEndocrinologyPhysiologyReproductive EndocrinologyReproductive PhysiologySteroid BiochemistryAndrogen PhysiologyMale Reproductive EndocrinologySteroid Hormone BiochemistrySteroid MetabolismTesticular FunctionTesticular PhysiologyAndrogen TransportDihydrotestosterone PhysiologyHigh SolubilitySolubilityTesticular BiochemistryTesticular DistributionTesticular HormonesTesticular Steroid Pharmacology
ALTHOUGH it has never been isolated from blood, testosterone is usually considered to be the circulating androgen secreted by the testis. With the demonstration by Bischoff (1948) of the high solubility of testosterone in serum albumin, it became possible to administer large doses of free testosterone dissolved in serum albumin intravenously and to study the fate, distribution, and excretion of circulating testosterone.