Palladium‐Catalyzed Asymmetric Allylation of Prochiral Nucleophiles: Synthesis of 3‐Allyl‐3‐Aryl Oxindoles

Abstract

Excellent yields and enantioselectivies are attained in the synthesis of 3-alkyl-3-aryl oxindoles based on the Pd-catalyzed asymmetric allylic alkylation (AAA) reaction. This approach utilizes a nonbasic hydroxylic additive in the transformation of 3-aryl oxindoles into complex, synthetically valuable oxindoles (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z460335_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.