Decreased Mivacurium Requirements and Delayed Neuromuscular Recovery During Sevoflurane Anesthesia in Children and Adults

Abstract

The mivacurium infusion requirement to maintain constant 90%-95% neuromuscular block during anesthesia is correlated with plasma cholinesterase activity. It is increased in children and reduced by the inhaled anesthetic sevoflurane. Despite the larger dose administered to children, recovery from block occurred more rapidly in children than in adults and was delayed by sevoflurane.