Sensory pulpal nerve fibres and trigeminal ganglion neurons express IL‐1RI: a potential mechanism for development of inflammatory hyperalgesia

Abstract

The localization of IL-1RI on sensory nerve fibres and its up-regulation in TG neurons during pulpal inflammation may imply a direct effect of IL-1 in pulpal nociception. The presence of IL-1RI on sympathetic nerve fibres and on blood vessels may indicate a vasoactive role of the same cytokine in the pulp.