Copper Iodide as a Recyclable Catalyst for Buchwald <i>N</i>‐Arylation

Abstract

Abstract An experimentally simple, efficient, and inexpensive catalyst system was developed for the N ‐arylation of indole, substituted indoles, pyrazole, imidazole, benzamide, morpholine, benzimidazole, thiobenzamide, aniline, benzylaniline, octylaniline, heptylaniline, and cyclohexylaniline with aryl iodides and bromides by using CuI as catalyst, trans ‐1,2‐diaminocyclohexane ( L1 ) as ligand, K 2 CO 3 as base, and water as solvent at 80 °C. The yields were excellent, and the catalytic system was recyclable up to four times without loss of catalytic activity.