Self-Association-Free and Recyclable, Dimeric Cinchona Alkaloid Organocatalysts for Methanolytic Desymmetrization of meso-Glutaric Anhydrides

Abstract

E-mail: s1673@skku.eduReceived March 7, 2011, Accepted March 11, 2011Key Words : Asymmetric organocatalysis, Bifunctional catalysis, Desymmetrization of meso-glutaric anhydrides,Squaramide-based dimeric cinchona alkaloid catalysts, Catalyst self-associationThere has been considerable interest in the stereoselectivering opening of meso-cyclic anhydrides, since the resultinghemiesters are used as versatile intermediates in the construc-tion of many bioactive compounds.