Primatone RL in mammalian cell culture media

Abstract

Over the past 50 years, many techniques for model based control have been developed. These techniques are typically applied to small-scale systems with up to ~10 states. From industry there is an increasing interest in applying model based control techniques to large-scale models that contain over 1;000 states. These models typically show up for systems that are described by partial differential equations, which are spatially discretized using finite elements or finite volume methods.<br/><br/>Due to computational limitations, it is in practice required to determine a controller that contains at most ~100 states. Therefore the problem of designing of a reduced order controller for a full order system is of great interest.