Shortening of Electromechanical Systole as a Manifestation of Excessive Adrenergic Stimulation in Acute Myocardial Infarction

Abstract

The relationship between shortened electromechanical systole (QS 2 I) and 24-hour urinary catecholamine excretion (E+NE) was studied in 51 patients admitted to the coronary care unit with suspected acute myocardial infarction. Among these patients, 24 had a documented acute myocardial infarction while 27 had chest pain without evidence of recent myocardial infarction. Patients receiving cardioactive drugs or with impaired renal function were excluded. Initial elevation of catecholamine excretion was found in 22 of 24 subjects with myocardial infarction and 14 patients without documented myocardial infarction. A close linear correlation (r = -0.82, P < 0.001) was noted between shortening of the QS 2 I and catecholamine excretion among all patients irrespective of the presence of documented infarction. Patients with serious arrhythmias had significantly higher levels of catecholamine excretion. In 13 patients with a short QS 2 I, 2.5 mg of propranolol given intravenously produced a significant lengthening of the QS 2 I while no change in the QS 2 I occurred in normal controls. This test provided useful corroborative evidence that the short QS 2 I was related to excessive adrenergic stimulation. In view of the current availability of effective beta-adrenergic blocking agents, these results may improve the selection of patients for antiarrhythmic therapy with these drugs.