Programmable Cell Adhesion Encoded by DNA Hybridization

Ravi A. Chandra, Erik S. Douglas, Richard A. Mathies, Carolyn R. Bertozzi, Matthew B. Francis

Angewandte Chemie International Edition · 2005 · 186 citations · 25 references

Concepts

Abstract

Stuck-on genes: Live cells functionalized with single-stranded DNA oligonucleotides bind, independent of native adhesion mechanisms, to substrates that bear complementary DNA strands in a sequence-specific manner. This strategy has been successfully utilized with several common mammalian cell lines and device platforms.

References

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