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Microbial hydroxylations of β-carboline derivatives
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1982
Year
Aromatic NucleusEthyl β-Carboline-3-carboxylateBiosynthesisBioorganic ChemistryEngineeringBiochemistryBiotransformationNatural SciencesBiocatalysisBiochemical EngineeringSporotrichum SulfurescensNatural Product BiosynthesisMicrobiologyCarbonyl MetabolismMicrobial HydroxylationsNatural Product Synthesis
Ethyl β-carboline-3-carboxylate (1a) and its 4-alkyl derivatives (1b–d) are hydroxylated by Sporotrichum sulfurescens at C-6 and C-8 of the aromatic nucleus; side chain hydroxylation of (1c) and (1d) occurs with Streptomyces lavendulae and Streptomyces griseus.