Nitric oxide inhibition aggravates ischemic damage of hippocampal but not of NADPH neurons in gerbils.

Abstract

These observations demonstrate that inhibition of endothelial and neuronal nitric oxide synthase activity does not modify resistance of nitric oxide-producing neurons to transient ischemia. The severe inhibition of nitric oxide production aggravates postischemic neuronal death in the hippocampus, whereas the mild inhibition is ineffective.