Manganese-Based Superoxide Dismutase Mimics Modify Both Acute and Long-Term Outcome Severity in a <i>Drosophila melanogaster</i> Model of Classic Galactosemia

Abstract

Our results confirm oxidative stress as a mediator of acute galactose sensitivity in GALT-null Drosophila larvae and demonstrate for the first time that oxidative stress may also contribute to galactose-independent adult outcomes in GALT deficiency. Finally, our results demonstrate for the first time that both MnTnBuOE-2-PyP(5+) and MnTE-2-PyP(5+) are bioavailable and effective when administered through an oral route in a D. melanogaster model of classic galactosemia.