Advanced Synthesis & Catalysis · 2005 · 59 citations · 2 references
Natural SciencesChemistryCatalysisOrganic ChemistryReaction EngineeringCross-coupling ReactionsHalogen ChemistryActivationC-h Bond ActivationOxidative CouplingOxidative Cross-coupling
Abstract Coupling of different halogenated acetanilides with acrylates using Pd‐catalyzed ortho ‐selective CH bond activation is reported. The yields of coupled products are low to high depending on the substrate. In general, arenes with electron‐rich substituents like methoxy and methyl groups gave higher yields of the coupled products. The presence of the halogen substituent did not interfere with the activation process under these conditions
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M.D.K. Boele, Gino P. F. van Strijdonck, André H. M. de Vries et al. · Journal of the American Chemical Society · 2002 · 615 citations · Full text