Pd‐Catalyzed <i>ortho</i>‐Selective Oxidative Coupling of Halogenated Acetanilides with Acrylates

George T. Lee, Xinglong Jiang, Kapa Prasad, Oljan Repič, Thomas J. Blacklock

Advanced Synthesis & Catalysis · 2005 · 59 citations · 2 references

Concepts

Abstract

Abstract Coupling of different halogenated acetanilides with acrylates using Pd‐catalyzed ortho ‐selective CH bond activation is reported. The yields of coupled products are low to high depending on the substrate. In general, arenes with electron‐rich substituents like methoxy and methyl groups gave higher yields of the coupled products. The presence of the halogen substituent did not interfere with the activation process under these conditions

References

2