Complete ¹H and 13C NMR structural assignments for a group of four goyazensolide-type furanoheliangolides - Concepedia

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Complete ¹H and 13C NMR structural assignments for a group of four goyazensolide-type furanoheliangolides

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2012

Year

Ana Carolina Ferreira Soares, Aline Nazaré Silva, Priscilla Mendonça Matos, Éder H. da Silva, Vladimir Constantino Gomes Heleno, Norberto Peporine Lopes, João Luís Callegari Lopes, Daiane Cristina Sass

Combinatorial ChemistryBioorganic ChemistryNmr Experimental TechniquesMolecular BiologyOrganic ChemistryChemistrySpectra-structure CorrelationComplete ¹HGoyazensolide-type FuranoheliangolidesStructure ElucidationBiochemistryNoe ExperimentsNmr Structural AssignmentsSolution Nmr SpectroscopyStructural BiologyNatural SciencesProtein NmrMain Group ChemistryMedicineNuclear Magnetic Resonance SpectroscopyGoyazensolide-type Sesquiterpene LactonesDrug Analysis

Abstract

Four goyazensolide-type sesquiterpene lactones - lychnofolide, centratherin, goyazensolide and goyazensolide acetate - were thoroughly studied by NMR experimental techniques. ¹H NMR, 13C NMR {¹H}, COSY, HMQC, HMBC, J-res. and NOE experiments were performed to provide the needed structural information. Complete and unequivocal assignment, including the determination of all multiplicities, was obtained for each structure and the data collections are presented in tables.