Methylglyoxal‐induced Fibronectin gene expression through Ras‐mediated NADPH oxidase activation in renal mesangial cells

Abstract

Induction of superxoide by Ras via p38 pathway activates fibrotic gene transcription of mesangial cells. Reduction of oxidative stress by scavenging superoxide may offer an alternative strategy for controlling MGO-induced renal fibrosis.