Short synthetic routes to sulphur-bridged analogues of 6,7-didehydroleukotriene B3

Abstract

Two extremely short routes to the 8,11-sulphur bridged leukotriene B3 analogue (2) are reported. Key steps involve (i) the introduction of the leukotriene C(1)–C(7) fragment by palladium-copper catalysed alkyne coupling reactions and, (ii) acylation of the thiophene tri-anion (7).