Concepedia

NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice

Stéphanie Carnésecchi, Christine Deffert, Alessandra Pagano, Sarah Garrido‐Urbani, Isabelle Ruchonnet-Métrailler, Michela Schäppi, Yves Donati, Michael A. Matthay, Karl‐Heinz Krause, Constance Barazzone Argiroffo

American Journal of Respiratory and Critical Care Medicine · 2009 · 161 citations · 46 references

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Abstract

NOX1 is an important contributor to ROS production and cell death of the alveolocapillary barrier during hyperoxia and is an upstream actor in oxidative stress-induced acute lung injury involving JNK and ERK pathways in mice.

References

46

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Hideaki Kamata, Shinichi Honda, Shin Maeda et al. · Cell · 2005 · 1.8K citations · Full text

, , +12

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

Jonathan Pollock, David A. Williams, Mary A. Gifford et al. · Nature Genetics · 1995 · 920 citations

, , +12

Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5

Guangjie Cheng, Zehong Cao, Xiang‐Xi Xu et al. · Gene · 2001 · 798 citations

, , +11

TNF-Induced Activation of the Nox1 NADPH Oxidase and Its Role in the Induction of Necrotic Cell Death

You‐Sun Kim, Michael K. Morgan, Swati Choksi et al. · Molecular Cell · 2007 · 513 citations · Full text

, , +13

Two Novel Proteins Activate Superoxide Generation by the NADPH Oxidase NOX1

Botond Bánfi, Robert A. Clark, Klaus Steger et al. · Journal of Biological Chemistry · 2003 · 478 citations · Full text