Concepedia

Overexpression of the R2 Subunit of Ribonucleotide Reductase in Human Nasopharyngeal Cancer Cells Reduces Radiosensitivity

Mei-Ling Kuo, Hwa-Shin Hwang, Patrick R. Sosnay, Keith A. Kunugi, Timothy J. Kinsella

The Cancer Journal · 2003 · 25 citations · 41 references

DOI

Abstract

An increase in R2 protein levels and RR activity in KB/M2 cells results in IR resistance, which appears mediated by enhanced IR damage repair during G2. R1 protein overexpression in these isogenic human tumor cells (KB/M1) did not affect RR activity or IR response.

References

41

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

Mark A. Bradford · Analytical Biochemistry · 1976 · 225.3K citations

, , +13

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Marion M. Bradford · Analytical Biochemistry · 1976 · 209.3K citations

, , +13

Randomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study

Charles W. Whitney, William T. Sause, Brian N. Bundy et al. · Journal of Clinical Oncology · 1999 · 1.5K citations · Full text

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Hiroshi Tanaka, Hirofumi Arakawa, Tatsuya Yamaguchi et al. · Nature · 2000 · 899 citations

, , +9

From RNA to DNA, Why So Many Ribonucleotide Reductases?

Peter Reichard · Science · 1993 · 530 citations

, , +16