Enhanced Erythrocyte Membrane Exposure of Phosphatidylserine Following Sorafenib Treatment: An<b><i>in vivo</i></b>and<b><i>in vitro</i></b>Study

Abstract

The present observations disclose novel effects of sorafenib, i.e. stimulation of suicidal erythrocyte death or eryptosis, which may contribute to the pathogenesis of anemia in Nexavar(®)-based chemotherapy.