Influence of Frozen-Section Analysis of Sentinel Lymph Node and Lumpectomy Margin Status on Reoperation Rates in Patients Undergoing Breast-Conservation Therapy

Abstract

Among patients having BCT with SLN biopsy, FS identified the positive SLN in 56% of patients with positive SLNs, allowing immediate ALND, and was false negative in 44%. Margin status remains a frequent indication for reoperation in BCT; routine FS analysis of the SLN ultimately saves only a minority of patients a second operation.