Effect of orally administered prostaglandin E1 on gastric secretion and gastrointestinal motility in man.

Abstract

The effects of prostaglandin E1 administered orally in doses of 10-40 mug/kg were studied in 3 healthy male subjects aged 30 31 and 38 years to determine whether the prostaglandin inhibited the secretion of gastric juices. There was no inhibition of pentagastrin-induced gastric secretion. After higher doses of prostaglandin were administered gastric juice contained large amounts of bile. Prostaglandin E1 administration also increased intestinal motility resulting in loose feces. The findings show that prostaglandin E1 administered orally in humans fails to inhibit gastric secretion in doses which have effects on gastrointestinal motility.